San Francisco 49ers vs. Arizona Cardinals Predictions, Picks, Odds | NFL Week 11 2022

Here are the 49ers vs Cardinals Predictions of the NFL Week 11.

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49ers vs Cardinals Prediction: To close out Week 11 of the NFL 2022, the San Francisco 49ers vs Arizona Cardinals will play each other on Monday Night Football in one of the last seasons held in the international games in Mexico City.

Talking about the San Francisco 49ers team, they have 2 victories in the past match. Both teams San Francisco 49ers (5-4) and Arizona Cardinals (4-6). At 8:15 p.m. ET on Monday, they play at Estadio Azteca in Mexico City. You can see the live score on ESPN & Prime Video.

The San Francisco 49ers vs. Arizona Cardinals game at the Azteca Stadium will be the first game played in Mexico since the 2019 season. 

49ers vs. Cardinals Prediction | NFL Week 11 Game on November 21, 2022

  • Where: Azteca Stadium – Mexico City, Mexico.
  • When: Monday, November 21, 2022, 8:15 PM E.T.

Betting on the San Francisco 49ers

  • Season record: 5-4
  • Spread: -8.0.
  • Moneyline: (-350).
  • Over/Under: 43.5.

With a victory over the Cardinals on Monday, the San Francisco 49ers will have a great chance to tie the Seahawks for first place in the NFC West.

They will have to rely on their strongest suit, defense, to accomplish this. The 49ers are among the top teams in the league at stopping opponents, giving up the fewest total yards (2,525) and first downs (149). Additionally, they allow the fewest points (163) and the fewest yards per carry (3.4), respectively, in the league, while their opponents only average 4.7 yards per play, which is the third-fewest in the league.

Since Christian McCaffrey joined the squad, the offense has progressively grown stronger. They no longer have to rely as heavily on passes because they can now run while carrying the ball. Prior to the arrival of the running back, they had only one game with more than 100 yards on the ground; however, thanks to McCaffrey, they now have three straight games with more than 100 yards on the ground.

Betting on Arizona Cardinals

  • Season record: 4-6.
  • Spread: +8.0.
  • Moneyline: (+280).
  • Over/Under: 43.5.

Arizona defeated the Rams last weekend to maintain its playoff hopes, but the team was dealt a devastating blow when tight end Zach Ertz sustained an injury. Additionally, there are concerns about Kyler Murray’s availability for Sunday’s game against San Francisco.

A Cardinals offense that hasn’t performed as expected and that will now play a team that doesn’t take many defensive liberties faces a serious challenge in this situation. With 230 points scored, they rank eighth, but their 4.9 yards per play average is the fourth-lowest in the league, their 5.2 net yards per play average is the second-lowest in the league, and they have committed 74 penalties, which is the second-highest number in the league.

Things don’t significantly improve defensively. They rank second in terms of points allowed (258), first downs allowed (217), passing touchdowns allowed (17), and red zone defense (27 touchdowns allowed in 40 visits, or 67.5%), making them the fifth worst team.

49ers vs. Cardinals picks and predictions

The 49ers seem to be in good shape to defeat a struggling division rival that is unsure whether or not its starting quarterback will suit up.

However, the San Francisco 49ers haven’t fared well in the recent past game. The underdog is 6-1-1 against the spread in their last eight games, while they are 1-7-1 in their last nine.

Prediction: 49ers 24, Cardinals 20

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